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Mechanically Regulated Outside-In Activation of an I-Domain-Containing Integrin

Integrins are heterodimeric transmembrane proteins that mediate cellular adhesion and bidirectional mechanotransductions through their conformational allostery. The allosteric pathway of an I-domain-containing integrin remains unclear because of its complexity and lack of effective experiments. For...

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Detalhes bibliográficos
Publicado no:Biophys J
Main Authors: Mao, Debin, Lü, Shouqin, Zhang, Xiao, Long, Mian
Formato: Artigo
Idioma:Inglês
Publicado em: The Biophysical Society 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7474184/
https://ncbi.nlm.nih.gov/pubmed/32814058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2020.07.022
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