Canagliflozin ameliorates renal oxidative stress and inflammation by stimulating AMPK–Akt–eNOS pathway in the isoprenaline-induced oxidative stress model

Diabetes is a leading cause of chronic kidney disease, and the high prevalence of sympathetic nervous system (SNS) hyperactivity in diabetic patients makes them further susceptible to SNS-mediated oxidative stress and accelerated kidney damage. Here, we investigated if canagliflozin can reverse isop...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Hasan, Raquibul, Lasker, Shoumen, Hasan, Ahasanul, Zerin, Farzana, Zamila, Mushfera, Parvez, Faisal, Rahman, Md. Mizanur, Khan, Ferdous, Subhan, Nusrat, Alam, Md. Ashraful
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7474058/
https://ncbi.nlm.nih.gov/pubmed/32887916
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-71599-2
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