Exoenzyme Y induces extracellular active caspase-7 accumulation independent from apoptosis: modulation of transmissible cytotoxicity

Caspase-3 and -7 are executioner caspases whose enzymatic activity is necessary to complete apoptotic cell death. Here, we questioned whether endothelial cell infection leads to caspase-3/7-mediated cell death. Pulmonary microvascular endothelial cells (PMVECs) were infected with Pseudomonas aerugin...

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Bibliographic Details
Published in:Am J Physiol Lung Cell Mol Physiol
Main Authors: Renema, Phoibe, Kozhukhar, Natalya, Pastukh, Viktoriya, Spadafora, Domenico, Paudel, Sunita Subedi, Tambe, Dhananjay T., Alexeyev, Mikhail, Frank, Dara W., Stevens, Troy
Format: Artigo
Language:Inglês
Published: American Physiological Society 2020
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7473935/
https://ncbi.nlm.nih.gov/pubmed/32579398
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00508.2019
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