Effects of germline DHFR and FPGS variants on methotrexate metabolism and relapse of leukemia

Methotrexate (MTX) during maintenance therapy is essential for curing acute lymphoblastic leukemia (ALL), but dosing strategies aiming at adequate treatment intensity are challenged by interindividual differences in drug disposition. To evaluate genetic factors associated with MTX metabolism, we per...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Tulstrup, Morten, Moriyama, Takaya, Jiang, Chuang, Grosjean, Marie, Nersting, Jacob, Abrahamsson, Jonas, Grell, Kathrine, Hjalgrim, Lisa Lyngsie, Jónsson, Ólafur Gísli, Kanerva, Jukka, Lund, Bendik, Nielsen, Stine Nygaard, Nielsen, Rikke Linnemann, Overgaard, Ulrik, Quist-Paulsen, Petter, Pruunsild, Kaie, Vaitkeviciene, Goda, Wolthers, Benjamin Ole, Zhang, Hui, Gupta, Ramneek, Yang, Jun J., Schmiegelow, Kjeld
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2020
Assuntos:
Lymphoid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7472715/
https://ncbi.nlm.nih.gov/pubmed/32391884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2020005064
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