Effects of germline DHFR and FPGS variants on methotrexate metabolism and relapse of leukemia

Methotrexate (MTX) during maintenance therapy is essential for curing acute lymphoblastic leukemia (ALL), but dosing strategies aiming at adequate treatment intensity are challenged by interindividual differences in drug disposition. To evaluate genetic factors associated with MTX metabolism, we per...

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Bibliografiset tiedot
Julkaisussa:Blood
Päätekijät: Tulstrup, Morten, Moriyama, Takaya, Jiang, Chuang, Grosjean, Marie, Nersting, Jacob, Abrahamsson, Jonas, Grell, Kathrine, Hjalgrim, Lisa Lyngsie, Jónsson, Ólafur Gísli, Kanerva, Jukka, Lund, Bendik, Nielsen, Stine Nygaard, Nielsen, Rikke Linnemann, Overgaard, Ulrik, Quist-Paulsen, Petter, Pruunsild, Kaie, Vaitkeviciene, Goda, Wolthers, Benjamin Ole, Zhang, Hui, Gupta, Ramneek, Yang, Jun J., Schmiegelow, Kjeld
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society of Hematology 2020
Aiheet:
Lymphoid Neoplasia
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7472715/
https://ncbi.nlm.nih.gov/pubmed/32391884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2020005064
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