Safety, Tolerability, Pharmacokinetics, and Concentration-QTc Analysis of Tetrodotoxin: A Randomized, Dose Escalation Study in Healthy Adults

Tetrodotoxin (TTX) is a highly specific voltage-gated sodium channel (VGSC) blocker in clinical evaluation as a peripheral-acting analgesic for chronic pain. This study presents the first published results of the safety including cardiac liability of TTX at therapeutic-relevant concentrations in twe...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Toxins (Basel)
Hlavní autoři: Kavoosi, Mojgan, O’Reilly, Terry E., Kavoosi, Mehran, Chai, Peng, Engel, Caroline, Korz, Walter, Gallen, Christopher C., Lester, Robert M.
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2020
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7472037/
https://ncbi.nlm.nih.gov/pubmed/32784930
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/toxins12080511
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky