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Prostaglandin E1 attenuates high glucose-induced apoptosis in proximal renal tubular cells by inhibiting the JNK/Bim pathway

Proximal renal tubular damage is a critical process underlying diabetic kidney disease (DKD). Our previous study shows that prostaglandin E1 (PGE1) reduces the apoptosis of renal tubular cells in DKD rats. But its underlying mechanisms remain unclear. In this study we investigated the protective eff...

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Bibliografiske detaljer
Udgivet i:Acta Pharmacol Sin
Main Authors: Zhang, Yu-han, Zhang, Ya-qin, Guo, Cong-cong, Wang, Li-kang, Cui, Yu-jiao, Dong, Jian-jun, Liao, Lin
Format: Artigo
Sprog:Inglês
Udgivet: Springer Singapore 2019
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7471471/
https://ncbi.nlm.nih.gov/pubmed/31685975
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41401-019-0314-9
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