A type IV collagenase inhibitor, N-hydroxy-3-phenyl-2-(4-phenylbenzenesulfonamido) propanamide (BiPS), suppresses skin injury induced by sulfur mustard

Sulfur mustard (SM) is a highly toxic blistering agent thought to mediate its action, in part, by activating matrix metalloproteinases (MMPs) in the skin and disrupting components of the basement membrane zone (BMZ). Type IV collagenases (MMP-9) degrade type IV collagen in the skin, a major componen...

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Udgivet i:Toxicol Appl Pharmacol
Main Authors: Chang, Yoke-Chen, Hahn, Rita A, Gordon, Marion K, Laskin, Jeffrey D, Gerecke, Donald R
Format: Artigo
Sprog:Inglês
Udgivet: 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7470515/
https://ncbi.nlm.nih.gov/pubmed/32479919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.taap.2020.115078
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