Advances in synthetic lethality for cancer therapy: cellular mechanism and clinical translation

Synthetic lethality is a lethal phenomenon in which the occurrence of a single genetic event is tolerable for cell survival, whereas the co-occurrence of multiple genetic events results in cell death. The main obstacle for synthetic lethality lies in the tumor biology heterogeneity and complexity, t...

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Bibliografiske detaljer
Udgivet i:J Hematol Oncol
Main Authors: Topatana, Win, Juengpanich, Sarun, Li, Shijie, Cao, Jiasheng, Hu, Jiahao, Lee, Jiyoung, Suliyanto, Kenneth, Ma, Diana, Zhang, Bin, Chen, Mingyu, Cai, Xiujun
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2020
Fag:
Review
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7470446/
https://ncbi.nlm.nih.gov/pubmed/32883316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13045-020-00956-5
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