Microfluidic concentration and separation of circulating tumor cell clusters from large blood volumes

Circulating tumor cells (CTCs) are extremely rare in the blood, yet they account for metastasis. Notably, it was reported that CTC clusters (CTCCs) can be 50–100 times more metastatic than single CTCs, making them particularly salient as a liquid biopsy target. Yet they can split apart and are even...

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Udgivet i:Lab Chip
Main Authors: Edd, Jon F., Mishra, Avanish, Dubash, Taronish D., Herrera, Stefan, Mohammad, Ridhwan, Kendall Williams, E., Hong, Xin, Mutlu, Baris R., Walsh, John R., de Carvalho, Fernanda Machado, Aldikacti, Berent, Nieman, Linda T., Stott, Shannon L., Kapur, Ravi, Maheswaran, Shyamala, Haber, Daniel A., Toner, Mehmet
Format: Artigo
Sprog:Inglês
Udgivet: 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7469923/
https://ncbi.nlm.nih.gov/pubmed/31934715
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c9lc01122f
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