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Synthetic lethality strategies: Beyond BRCA1/2 mutations in pancreatic cancer
Cancer cells are often characterized by abnormalities in DNA damage response including defects in cell cycle checkpoints and/or DNA repair. Synthetic lethality between DNA damage repair (DDR) pathways has provided a paradigm for cancer therapy by targeting DDR. The successful example is that cancer...
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| Veröffentlicht in: | Cancer Sci |
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| Hauptverfasser: | , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
John Wiley and Sons Inc.
2020
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7469842/ https://ncbi.nlm.nih.gov/pubmed/32639661 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cas.14565 |
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