cDC1 prime and are licensed by CD4 T cells to induce anti-tumour immunity

Conventional type 1 dendritic cells (cDC1s(1)) are thought to perform antigen cross-presentation required to prime CD8 T cells(2,3), while cDC2 are considered specialized for priming CD4 T cells(4,5). CD4 T cells are also thought to help CD8 T cell responses through a variety of mechanisms(6–11), in...

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Veröffentlicht in:Nature
Hauptverfasser: Ferris, Stephen T., Durai, Vivek, Wu, Renee, Theisen, Derek J., Ward, Jeffrey P., Bern, Michael D., Davidson, Jesse T., Bagadia, Prachi, Liu, Tiantian, Briseño, Carlos G., Li, Lijin, Gillanders, William E., Wu, Gregory F., Yokoyama, Wayne M., Murphy, Theresa L., Schreiber, Robert D., Murphy, Kenneth M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7469755/
https://ncbi.nlm.nih.gov/pubmed/32788723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-020-2611-3
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