Stabilization of MORC2 by estrogen and antiestrogens through GPER1- PRKACA-CMA pathway contributes to estrogen-induced proliferation and endocrine resistance of breast cancer cells

Aberrant activation of estrogen signaling through three ESR (estrogen receptor) subtypes, termed ESR1/ERα, ESR2/ERβ, and GPER1 (G protein-coupled estrogen receptor 1), is implicated in breast cancer pathogenesis and progression. Antiestrogens tamoxifen (TAM) and fulvestrant (FUL) are effective for t...

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Bibliografiske detaljer
Udgivet i:Autophagy
Main Authors: Yang, Fan, Xie, Hong-Yan, Yang, Li-Feng, Zhang, Lin, Zhang, Fang-Lin, Liu, Hong-Yi, Li, Da-Qiang, Shao, Zhi-Ming
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2019
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7469550/
https://ncbi.nlm.nih.gov/pubmed/32401166
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2019.1659609
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