Hypoxia-induced autophagy drives colorectal cancer initiation and progression by activating the PRKC/PKC-EZR (ezrin) pathway

In solid tumors, cancer stem cells (CSCs) or tumor-initiating cells (TICs) are often found in hypoxic niches. Nevertheless, the influence of hypoxia on TICs is poorly understood. Using previously established, TIC-enrichedpatient-derived colorectal cancer (CRC) cultures, we show that hypoxia increase...

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書目詳細資料
發表在:Autophagy
Main Authors: Qureshi-Baig, Komal, Kuhn, Diana, Viry, Elodie, Pozdeev, Vitaly I., Schmitz, Martine, Rodriguez, Fabien, Ullmann, Pit, Koncina, Eric, Nurmik, Martin, Frasquilho, Sonia, Nazarov, Petr V., Zuegel, Nikolaus, Boulmont, Marc, Karapetyan, Yervand, Antunes, Laurent, Val, Daniel, Mittelbronn, Michel, Janji, Bassam, Haan, Serge, Letellier, Elisabeth
格式: Artigo
語言:Inglês
出版: Taylor & Francis 2019
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Research Paper
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7469473/
https://ncbi.nlm.nih.gov/pubmed/31775562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2019.1687213
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