Hypoxia-induced autophagy drives colorectal cancer initiation and progression by activating the PRKC/PKC-EZR (ezrin) pathway

In solid tumors, cancer stem cells (CSCs) or tumor-initiating cells (TICs) are often found in hypoxic niches. Nevertheless, the influence of hypoxia on TICs is poorly understood. Using previously established, TIC-enrichedpatient-derived colorectal cancer (CRC) cultures, we show that hypoxia increase...

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Detalles Bibliográficos
Publicado en:Autophagy
Autores principales: Qureshi-Baig, Komal, Kuhn, Diana, Viry, Elodie, Pozdeev, Vitaly I., Schmitz, Martine, Rodriguez, Fabien, Ullmann, Pit, Koncina, Eric, Nurmik, Martin, Frasquilho, Sonia, Nazarov, Petr V., Zuegel, Nikolaus, Boulmont, Marc, Karapetyan, Yervand, Antunes, Laurent, Val, Daniel, Mittelbronn, Michel, Janji, Bassam, Haan, Serge, Letellier, Elisabeth
Formato: Artigo
Lenguaje:Inglês
Publicado: Taylor & Francis 2019
Materias:
Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7469473/
https://ncbi.nlm.nih.gov/pubmed/31775562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2019.1687213
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