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S1PR1 and VEGFR2 – a synergy that promotes tumor angiogenesis?
We have recently uncovered that endothelial cell (EC) S1PR1 controls the effectiveness of VEGFR2 driven tumor angiogenesis. By using tumor ECs, EC-S1PR1(−/-) mice and S1PR1 antagonist, we showed that VEGF-VEGFR2 pathway requires EC-S1PR1-induced signaling to efficiently drive tumor vascularization a...
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| Gepubliceerd in: | Mol Cell Oncol |
|---|---|
| Hoofdauteurs: | , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
Taylor & Francis
2020
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7469464/ https://ncbi.nlm.nih.gov/pubmed/32944615 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/23723556.2020.1746131 |
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