S1PR1 and VEGFR2 – a synergy that promotes tumor angiogenesis?

We have recently uncovered that endothelial cell (EC) S1PR1 controls the effectiveness of VEGFR2 driven tumor angiogenesis. By using tumor ECs, EC-S1PR1(−/-) mice and S1PR1 antagonist, we showed that VEGF-VEGFR2 pathway requires EC-S1PR1-induced signaling to efficiently drive tumor vascularization a...

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Foilsithe in:Mol Cell Oncol
Main Authors: Balaji Ragunathrao, Vijay Avin, Vellingiri, Vigneshwaran, Anwar, Mumtaz, Akhter, Md Zahid, Mehta, Dolly
Formáid: Artigo
Teanga:Inglês
Foilsithe: Taylor & Francis 2020
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Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7469464/
https://ncbi.nlm.nih.gov/pubmed/32944615
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/23723556.2020.1746131
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