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AZD9291 inactivates the PRC2 complex to mediate tumor growth inhibition
Deregulated Polycomb repressive complex 2 (PRC2) is intimately involved in tumorigenesis and progression, making it an invaluable target for epigenetic cancer therapy. Disrupting the EZH2–EED interaction, which is required for PRC2 enzymatic activity, is a promising strategy for cancer treatment. Ho...
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| Pubblicato in: | Acta Pharmacol Sin |
|---|---|
| Autori principali: | , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Springer Singapore
2019
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7468275/ https://ncbi.nlm.nih.gov/pubmed/31171828 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41401-019-0248-2 |
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