Metabolic but not transcriptional regulation by PKM2 is important for natural killer cell responses

Natural Killer (NK) cells have an important role in immune responses to viruses and tumours. Integrating changes in signal transduction pathways and cellular metabolism is essential for effective NK cells responses. The glycolytic enzyme Pyruvate Kinase Muscle 2 (PKM2) has described roles in regulat...

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Veröffentlicht in:eLife
Hauptverfasser: Walls, Jessica F, Subleski, Jeff J, Palmieri, Erika M, Gonzalez-Cotto, Marieli, Gardiner, Clair M, McVicar, Daniel W, Finlay, David K
Format: Artigo
Sprache:Inglês
Veröffentlicht: eLife Sciences Publications, Ltd 2020
Schlagworte:
Cell Biology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7467725/
https://ncbi.nlm.nih.gov/pubmed/32812866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.59166
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