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Raman Spectroscopy to Monitor Post-Translational Modifications and Degradation in Monoclonal Antibody Therapeutics

[Image: see text] Monoclonal antibodies (mAbs) represent a rapidly expanding market for biotherapeutics. Structural changes in the mAb can lead to unwanted immunogenicity, reduced efficacy, and loss of material during production. The pharmaceutical sector requires new protein characterization tools...

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Detalles Bibliográficos
Publicado en:Anal Chem
Main Authors: McAvan, Bethan S., Bowsher, Leo A., Powell, Thomas, O’Hara, John F., Spitali, Mariangela, Goodacre, Royston, Doig, Andrew J.
Formato: Artigo
Idioma:Inglês
Publicado: American Chemical Society 2020
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7467412/
https://ncbi.nlm.nih.gov/pubmed/32614170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.analchem.0c00627
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