Raman Spectroscopy to Monitor Post-Translational Modifications and Degradation in Monoclonal Antibody Therapeutics

[Image: see text] Monoclonal antibodies (mAbs) represent a rapidly expanding market for biotherapeutics. Structural changes in the mAb can lead to unwanted immunogenicity, reduced efficacy, and loss of material during production. The pharmaceutical sector requires new protein characterization tools...

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Bibliographic Details
Published in:Anal Chem
Main Authors: McAvan, Bethan S., Bowsher, Leo A., Powell, Thomas, O’Hara, John F., Spitali, Mariangela, Goodacre, Royston, Doig, Andrew J.
Format: Artigo
Language:Inglês
Published: American Chemical Society 2020
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7467412/
https://ncbi.nlm.nih.gov/pubmed/32614170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.analchem.0c00627
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