Discovery of HIV entry inhibitors via a hybrid CXCR4 and CCR5 receptor pharmacophore‐based virtual screening approach

Chemokine receptors are key regulators of cell migration in terms of immunity and inflammation. Among these, CCR5 and CXCR4 play pivotal roles in cancer metastasis and HIV-1 transmission and infection. They act as essential co-receptors for HIV and furnish a route to the cell entry. In particular, i...

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Udgivet i:Eur J Pharm Sci
Main Authors: Mirza, Muhammad Usman, Saadabadi, Atefeh, Vanmeert, Michiel, Salo-Ahen, Outi M.H., Abdullah, Iskandar, Claes, Sandra, De Jonghe, Steven, Schols, Dominique, Ahmad, Sarfraz, Froeyen, Matheus
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier B.V. 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7467125/
https://ncbi.nlm.nih.gov/pubmed/32890663
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejps.2020.105537
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