NCS 613, a Potent PDE4 Inhibitor, Displays Anti-Inflammatory and Anti-Proliferative Properties on A549 Lung Epithelial Cells and Human Lung Adenocarcinoma Explants

Chronic inflammation is a deleterious process occurring in several pulmonary diseases; it is a driving force promoting tumorigenesis. By regulating local cyclic nucleotide concentration, cyclic nucleotide phosphodiesterases (PDE) govern important biological processes, including inflammation and prol...

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Bibliographic Details
Published in:Front Pharmacol
Main Authors: Yougbare, Issaka, Belemnaba, Lazare, Morin, Caroline, Abusnina, Abdurazzag, Senouvo, Yannick F., Keravis, Thérèse, Lugnier, Claire, Rousseau, Eric
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2020
Subjects:
Pharmacology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7466439/
https://ncbi.nlm.nih.gov/pubmed/32973507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2020.01266
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