Expression Profile of SARS-CoV-2 Host Receptors in Human Pancreatic Islets Revealed Upregulation of ACE2 in Diabetic Donors

Cellular entry of SARS-CoV-2 is thought to occur through the binding of viral spike S1 protein to ACE2. The entry process involves priming of the S protein by TMPRSS2 and ADAM17, which collectively mediate the binding and promote ACE2 shedding. In this study, microarray and RNA-sequencing (RNA-seq)...

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Vydáno v:Biology (Basel)
Hlavní autoři: Taneera, Jalal, El-Huneidi, Waseem, Hamad, Mawieh, Mohammed, Abdul Khader, Elaraby, Esraa, Hachim, Mahmood Yaseen
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2020
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7465557/
https://ncbi.nlm.nih.gov/pubmed/32784802
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biology9080215
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