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PARP Inhibitor Resistance Mechanisms and Implications for Post-Progression Combination Therapies

The use of PARP inhibitors (PARPi) is growing widely as FDA approvals have shifted its use from the recurrence setting to the frontline setting. In parallel, the population developing PARPi resistance is increasing. Here we review the role of PARP, DNA damage repair, and synthetic lethality. We disc...

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Detalhes bibliográficos
Publicado no:Cancers (Basel)
Main Authors: Lee, Elizabeth K., Matulonis, Ursula A.
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7465003/
https://ncbi.nlm.nih.gov/pubmed/32722408
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers12082054
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