Profound Reprogramming towards Stemness in Pancreatic Cancer Cells as Adaptation to AKT Inhibition

Cancer cells acquire resistance to cytotoxic therapies targeting major survival pathways by adapting their metabolism. The AKT pathway is a major regulator of human pancreatic adenocarcinoma progression and a key pharmacological target. The mechanisms of adaptation to long-term silencing of AKT isof...

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Veröffentlicht in:Cancers (Basel)
Hauptverfasser: Arasanz, Hugo, Hernández, Carlos, Bocanegra, Ana, Chocarro, Luisa, Zuazo, Miren, Gato, Maria, Ausin, Karina, Santamaría, Enrique, Fernández-Irigoyen, Joaquín, Fernandez, Gonzalo, Santamaria, Eva, Rodríguez, Carlos, Blanco-Luquin, Idoia, Vera, Ruth, Escors, David, Kochan, Grazyna
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7464748/
https://ncbi.nlm.nih.gov/pubmed/32764385
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers12082181
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