Trabectedin and Lurbinectedin Extend Survival of Mice Bearing C26 Colon Adenocarcinoma, without Affecting Tumor Growth or Cachexia

Trabectedin (ET743) and lurbinectedin (PM01183) limit the production of inflammatory cytokines that are elevated during cancer cachexia. Mice carrying C26 colon adenocarcinoma display cachexia (i.e., premature death and body wasting with muscle, fat and cardiac tissue depletion), high levels of infl...

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Detalhes bibliográficos
Publicado no:Cancers (Basel)
Main Authors: Aquila, Giorgio, Re Cecconi, Andrea David, Forti, Mara, Frapolli, Roberta, Bello, Ezia, Novelli, Deborah, Russo, Ilaria, Licandro, Simonetta Andrea, Staszewsky, Lidia, Martinelli, Giulia Benedetta, Talamini, Laura, Pasetto, Laura, Resovi, Andrea, Giavazzi, Raffaella, Scanziani, Eugenio, Careccia, Giorgia, Vénéreau, Emilie, Masson, Serge, Latini, Roberto, D’Incalci, Maurizio, Piccirillo, Rosanna
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7463843/
https://ncbi.nlm.nih.gov/pubmed/32824440
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers12082312
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