Wird geladen...
Conformational Restriction of Histamine with a Rigid Bicyclo[3.1.0]hexane Scaffold Provided Selective H(3) Receptor Ligands
We designed and synthesized conformationally rigid histamine analogues with a bicyclo[3.1.0]hexane scaffold. All the compounds were selectively bound to the H(3) receptor subtype over the H(4) receptor subtype. Notably, compound 7 showed potent binding affinity and over 100-fold selectivity for the...
Gespeichert in:
| Veröffentlicht in: | Molecules |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
MDPI
2020
|
| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7463632/ https://ncbi.nlm.nih.gov/pubmed/32764432 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules25163562 |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|