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Conformational Restriction of Histamine with a Rigid Bicyclo[3.1.0]hexane Scaffold Provided Selective H(3) Receptor Ligands
We designed and synthesized conformationally rigid histamine analogues with a bicyclo[3.1.0]hexane scaffold. All the compounds were selectively bound to the H(3) receptor subtype over the H(4) receptor subtype. Notably, compound 7 showed potent binding affinity and over 100-fold selectivity for the...
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| Publié dans: | Molecules |
|---|---|
| Auteurs principaux: | , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
MDPI
2020
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7463632/ https://ncbi.nlm.nih.gov/pubmed/32764432 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules25163562 |
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