Anti-Proliferative and Pro-Apoptotic Effects of Short-Term Inhibition of Telomerase In Vivo and in Human Malignant B Cells Xenografted in Zebrafish

Besides its canonical role in stabilizing telomeres, telomerase reverse transcriptase (TERT) may promote tumor growth/progression through extra-telomeric functions. Our previous in vitro studies demonstrated that short-term TERT inhibition by BIBR1532 (BIBR), an inhibitor of TERT catalytic activity,...

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發表在:Cancers (Basel)
Main Authors: Giunco, Silvia, Zangrossi, Manuela, Dal Pozzolo, Francesca, Celeghin, Andrea, Ballin, Giovanni, Petrara, Maria Raffaella, Amin, Aamir, Argenton, Francesco, Godinho Ferreira, Miguel, De Rossi, Anita
格式: Artigo
語言:Inglês
出版: MDPI 2020
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7463531/
https://ncbi.nlm.nih.gov/pubmed/32722398
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers12082052
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