FGFR1 clustering with engineered tetravalent antibody improves the efficiency and modifies the mechanism of receptor internalization

Fibroblast growth factor receptor 1 (FGFR1) transmits signals through the plasma membrane regulating essential cellular processes like division, motility, metabolism, and death. Overexpression of FGFR1 is observed in numerous tumors and thus constitutes an attractive molecular target for selective c...

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Vydáno v:Mol Oncol
Hlavní autoři: Pozniak, Marta, Sokolowska‐Wedzina, Aleksandra, Jastrzebski, Kamil, Szymczyk, Jakub, Porebska, Natalia, Krzyscik, Mateusz Adam, Zakrzewska, Malgorzata, Miaczynska, Marta, Otlewski, Jacek, Opalinski, Lukasz
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2020
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7463352/
https://ncbi.nlm.nih.gov/pubmed/32511887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/1878-0261.12740
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