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Promoter Proximal Pausing Limits Tumorous Growth Induced by the Yki Transcription Factor in Drosophila

Promoter proximal pausing (PPP) of RNA polymerase II has emerged as a crucial rate-limiting step in the regulation of gene expression. Regulation of PPP is brought about by complexes 7SK snRNP, P-TEFb (Cdk9/cycT), and the negative elongation factor (NELF), which are highly conserved from Drosophila...

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Detalhes bibliográficos
Publicado no:Genetics
Main Authors: Nagarkar, Sanket, Wasnik, Ruchi, Govada, Pravallika, Cohen, Stephen, Shashidhara, L. S.
Formato: Artigo
Idioma:Inglês
Publicado em: Genetics Society of America 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7463282/
https://ncbi.nlm.nih.gov/pubmed/32737120
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.120.303419
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