Substitution of Thr572 to Ala in mouse c-Myb attenuates progression of early erythroid differentiation

The expression level of transcription factor c-Myb oscillates during hematopoiesis. Fbw7 promotes ubiquitin-mediated degradation of c-Myb, which is dependent on phosphorylation of Thr572. To investigate the physiological relevance of Fbw7-mediated c-Myb degradation, we generated mutant mice carrying...

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Udgivet i:Sci Rep
Main Authors: Kitagawa, Kyoko, Uchida, Chiharu, Horiguchi, Ryo, Ohhata, Tatsuya, Sakai, Satoshi, Niida, Hiroyuki, Yasumoto, Shuhei, Handa, Yukino, Suzuki, Moena, Hashimoto, Masako, Tazawa, Toshiyasu, Yokochi, Yuta, Tsuji, Mayumi, Kitagawa, Masatoshi
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7463259/
https://ncbi.nlm.nih.gov/pubmed/32873855
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-71267-5
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