Dual targeting of NUAK1 and ULK1 using the multitargeted inhibitor MRT68921 exerts potent antitumor activities

Utilizing oxidative stress has recently been regarded as a potential strategy for tumor therapy. The NUAK family SNF1-like kinase 1 (NUAK1) is a critical component of the antioxidant defense system and is necessary for the survival of tumors. Therefore, NUAK1 is considered an attractive therapeutic...

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Pubblicato in:Cell Death Dis
Autori principali: Chen, Yiran, Xie, Xiaoling, Wang, Chunsheng, Hu, Yuxing, Zhang, Honghao, Zhang, Lenghe, Tu, Sanfang, He, Yanjie, Li, Yuhua
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7463258/
https://ncbi.nlm.nih.gov/pubmed/32873786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-020-02885-0
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