Quantifying drug tissue biodistribution by integrating high content screening with deep-learning analysis

Quantitatively determining in vivo achievable drug concentrations in targeted organs of animal models and subsequent target engagement confirmation is a challenge to drug discovery and translation due to lack of bioassay technologies that can discriminate drug binding with different mechanisms. We h...

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Pubblicato in:Sci Rep
Autori principali: Li, Zhuyin, Xiao, Youping, Peng, Jia, Locke, Darren, Holmes, Derek, Li, Lei, Hamilton, Shannon, Cook, Erica, Myer, Larnie, Vanderwall, Dana, Cloutier, Normand, Siddiqui, Akbar M., Whitehead, Paul, Bishop, Richard, Zhao, Lei, Cvijic, Mary Ellen
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7463244/
https://ncbi.nlm.nih.gov/pubmed/32873881
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-71347-6
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