Cryo-EM structure of the fully-loaded asymmetric anthrax lethal toxin in its heptameric pre-pore state

Anthrax toxin is the major virulence factor secreted by Bacillus anthracis, causing high mortality in humans and other mammals. It consists of a membrane translocase, known as protective antigen (PA), that catalyzes the unfolding of its cytotoxic substrates lethal factor (LF) and edema factor (EF),...

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Udgivet i:PLoS Pathog
Main Authors: Antoni, Claudia, Quentin, Dennis, Lang, Alexander E., Aktories, Klaus, Gatsogiannis, Christos, Raunser, Stefan
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2020
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7462287/
https://ncbi.nlm.nih.gov/pubmed/32810181
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1008530
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