Neural stem cells restore myelin in a demyelinating model of Pelizaeus-Merzbacher disease

Pelizaeus-Merzbacher disease is a fatal X-linked leukodystrophy caused by mutations in the PLP1 gene, which is expressed in the CNS by oligodendrocytes. Disease onset, symptoms and mortality span a broad spectrum depending on the nature of the mutation and thus the degree of CNS hypomyelination. In...

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Detalhes bibliográficos
Publicado no:Brain
Main Authors: Gruenenfelder, Fredrik I, McLaughlin, Mark, Griffiths, Ian R, Garbern, James, Thomson, Gemma, Kuzman, Peter, Barrie, Jennifer A, McCulloch, Maj-lis, Penderis, Jacques, Stassart, Ruth, Nave, Klaus-Armin, Edgar, Julia M
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
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Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7462093/
https://ncbi.nlm.nih.gov/pubmed/32419025
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/brain/awaa080
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