LyP-1-Modified Oncolytic Adenoviruses Targeting Transforming Growth Factor β Inhibit Tumor Growth and Metastases and Augment Immune Checkpoint Inhibitor Therapy in Breast Cancer Mouse Models

We report here the development of oncolytic adenoviruses (Ads) that have reduced toxicity, enhanced tumor tropism, produce strong antitumor response, and can overcome resistance to immune checkpoint inhibitor therapy in breast cancer. We have shown that LyP-1 receptor (p32) is highly expressed on th...

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Detalhes bibliográficos
Publicado no:Hum Gene Ther
Main Authors: Xu, Weidong, Yang, Yuefeng, Hu, Zebin, Head, Maria, Mangold, Kathy A., Sullivan, Megan, Wang, Edward, Saha, Poornima, Gulukota, Kamalakar, Helseth, Donald L., Guise, Theresa, Prabhkar, Bellur S., Kaul, Karen, Schreiber, Hans, Seth, Prem
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc., publishers 2020
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7462024/
https://ncbi.nlm.nih.gov/pubmed/32394753
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hum.2020.078
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