Consequences of CRISPR-Cas9-Mediated CFTR Knockout in Human Macrophages

Macrophage dysfunction is fundamentally related to altered immunity in cystic fibrosis (CF). How genetic deficits in the cystic fibrosis transmembrane conductance regulator (CFTR) lead to these defects remains unknown. Rapid advances in genomic editing such as the clustered regularly interspaced sho...

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Detalles Bibliográficos
Publicado en:Front Immunol
Autores principales: Zhang, Shuzhong, Shrestha, Chandra L., Wisniewski, Benjamin L., Pham, Hanh, Hou, Xucheng, Li, Wenqing, Dong, Yizhou, Kopp, Benjamin T.
Formato: Artigo
Lenguaje:Inglês
Publicado: Frontiers Media S.A. 2020
Materias:
Immunology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7461958/
https://ncbi.nlm.nih.gov/pubmed/32973772
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.01871
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