Augmenting the Effectiveness of CAR-T Cells by Enhanced Self-Delivery of PD-1-Neutralizing scFv

Chimeric antigen receptor T (CAR-T) cell therapy is not satisfying in solid tumors. PD-1-mediated suppression greatly hinders CAR-T cells in the microenvironment. It has been shown that PD-1 blockade improves the effectiveness of CAR-T cells. Herein, we designed CAR-T cells than could secret α-PD-1...

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Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Front Cell Dev Biol
Päätekijät: Ping, Yu, Li, Feng, Nan, Shufeng, Zhang, Daiqun, Shi, Xiaojuan, Shan, Jiqi, Zhang, Yi
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Frontiers Media S.A. 2020
Aiheet:
Cell and Developmental Biology
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7461868/
https://ncbi.nlm.nih.gov/pubmed/32974346
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcell.2020.00803
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