Decitabine-Mediated Epigenetic Reprograming Enhances Anti-leukemia Efficacy of CD123-Targeted Chimeric Antigen Receptor T-Cells

Chimeric antigen receptor (CAR) T cells represent a potentially curative therapy for patients with advanced hematological cancers; however, uncertainties surround the cell-intrinsic fitness as well as the exhaustion that restrict the capacity of CAR-T. Decitabine (DAC), a DNA demethylating agent, ha...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: You, Liangshun, Han, Qingmei, Zhu, Li, Zhu, Yijing, Bao, Changqian, Yang, Chunmei, Lei, Wen, Qian, Wenbin
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7461863/
https://ncbi.nlm.nih.gov/pubmed/32973749
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.01787
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