Targeted Co-delivery of Tumor Antigen and α-Galactosylceramide to CD141(+) Dendritic Cells Induces a Potent Tumor Antigen-Specific Human CD8(+) T Cell Response in Human Immune System Mice

Active co-delivery of tumor antigens (Ag) and α-galactosylceramide (α-GalCer), a potent agonist for invariant Natural Killer T (iNKT) cells, to cross-priming CD8α(+) dendritic cells (DCs) was previously shown to promote strong anti-tumor responses in mice. Here, we designed a nanoparticle-based vacc...

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Bibliographic Details
Published in:Front Immunol
Main Authors: Huang, Jing, Zhou, Jing, Ghinnagow, Reem, Seki, Toshiyuki, Iketani, Sho, Soulard, Daphnée, Paczkowski, Patrick, Tsuji, Yukiko, MacKay, Sean, Cruz, Luis Javier, Trottein, François, Tsuji, Moriya
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2020
Subjects:
Immunology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7461784/
https://ncbi.nlm.nih.gov/pubmed/32973811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.02043
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