TRAF3 Modulation: Novel Mechanism for the Anti-inflammatory Effects of the Vitamin D Receptor Agonist Paricalcitol in Renal Disease

BACKGROUND: CKD leads to vitamin D deficiency. Treatment with vitamin D receptor agonists (VDRAs) may have nephroprotective and anti-inflammatory actions, but their mechanisms of action are poorly understood. METHODS: Modulation of the noncanonical NF-κB2 pathway and its component TNF receptor–assoc...

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Vydáno v:J Am Soc Nephrol
Hlavní autoři: Rayego-Mateos, Sandra, Morgado-Pascual, Jose Luis, Valdivielso, José Manuel, Sanz, Ana Belén, Bosch-Panadero, Enrique, Rodrigues-Díez, Raúl R., Egido, Jesús, Ortiz, Alberto, González-Parra, Emilio, Ruiz-Ortega, Marta
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Nephrology 2020
Témata:
Basic Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7461676/
https://ncbi.nlm.nih.gov/pubmed/32631974
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2019111206
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