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Genetically encoding thyronine for fluorescent detection of peroxynitrite
Peroxynitrite is a highly reactive oxidant effecting cell signaling and cell death. Here we report a fluorescent protein probe to selectively detect peroxynitrite. A novel unnatural amino acid, thyronine (Thy), was genetically encoded in E. coli and mammalian cells by evolving an orthogonal tRNA(Pyl...
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| Yayımlandı: | Bioorg Med Chem |
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| Asıl Yazarlar: | , , , , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
2020
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7461609/ https://ncbi.nlm.nih.gov/pubmed/32828428 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2020.115665 |
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