Structural Characterization of Covalently Stabilized Human Cystatin C Oligomers

Human cystatin C (HCC), a cysteine-protease inhibitor, exists as a folded monomer under physiological conditions but has the ability to self-assemble via domain swapping into multimeric states, including oligomers with a doughnut-like structure. The structure of the monomeric HCC has been solved by...

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Veröffentlicht in:Int J Mol Sci
Hauptverfasser: Chrabąszczewska, Magdalena, Sieradzan, Adam K., Rodziewicz-Motowidło, Sylwia, Grubb, Anders, Dobson, Christopher M., Kumita, Janet R., Kozak, Maciej
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7461555/
https://ncbi.nlm.nih.gov/pubmed/32824145
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21165860
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