Allosteric Inhibition of the SARS‐CoV‐2 Main Protease: Insights from Mass Spectrometry Based Assays

The SARS‐CoV‐2 main protease (M(pro)) cleaves along the two viral polypeptides to release non‐structural proteins required for viral replication. M(Pro) is an attractive target for antiviral therapies to combat the coronavirus‐2019 disease. Here, we used native mass spectrometry to characterize the...

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Dades bibliogràfiques
Publicat a:Angew Chem Int Ed Engl
Autors principals: El‐Baba, Tarick J., Lutomski, Corinne A., Kantsadi, Anastassia L., Malla, Tika R., John, Tobias, Mikhailov, Victor, Bolla, Jani R., Schofield, Christopher J., Zitzmann, Nicole, Vakonakis, Ioannis, Robinson, Carol V.
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2020
Matèries:
Communications
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7461284/
https://ncbi.nlm.nih.gov/pubmed/32841477
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.202010316
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