Allosteric Inhibition of the SARS‐CoV‐2 Main Protease: Insights from Mass Spectrometry Based Assays

The SARS‐CoV‐2 main protease (M(pro)) cleaves along the two viral polypeptides to release non‐structural proteins required for viral replication. M(Pro) is an attractive target for antiviral therapies to combat the coronavirus‐2019 disease. Here, we used native mass spectrometry to characterize the...

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Detalhes bibliográficos
Publicado no:Angew Chem Int Ed Engl
Main Authors: El‐Baba, Tarick J., Lutomski, Corinne A., Kantsadi, Anastassia L., Malla, Tika R., John, Tobias, Mikhailov, Victor, Bolla, Jani R., Schofield, Christopher J., Zitzmann, Nicole, Vakonakis, Ioannis, Robinson, Carol V.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
Assuntos:
Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7461284/
https://ncbi.nlm.nih.gov/pubmed/32841477
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.202010316
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