Epithelial Vasopressin Type-2 Receptors Regulate Myofibroblasts by a YAP-CCN2–Dependent Mechanism in Polycystic Kidney Disease

BACKGROUND: Fibrosis is a major cause of loss of renal function in autosomal dominant polycystic kidney disease (ADPKD). In this study, we examined whether vasopressin type-2 receptor (V2R) activity in cystic epithelial cells can stimulate interstitial myofibroblasts and fibrosis in ADPKD kidneys. M...

詳細記述

保存先:
書誌詳細
出版年:J Am Soc Nephrol
主要な著者: Dwivedi, Nidhi, Tao, Shixin, Jamadar, Abeda, Sinha, Sonali, Howard, Christianna, Wallace, Darren P., Fields, Timothy A., Leask, Andrew, Calvet, James P., Rao, Reena
フォーマット: Artigo
言語:Inglês
出版事項: American Society of Nephrology 2020
主題:
Basic Research
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC7460894/
https://ncbi.nlm.nih.gov/pubmed/32554753
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2020020190
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