Epithelial Vasopressin Type-2 Receptors Regulate Myofibroblasts by a YAP-CCN2–Dependent Mechanism in Polycystic Kidney Disease

BACKGROUND: Fibrosis is a major cause of loss of renal function in autosomal dominant polycystic kidney disease (ADPKD). In this study, we examined whether vasopressin type-2 receptor (V2R) activity in cystic epithelial cells can stimulate interstitial myofibroblasts and fibrosis in ADPKD kidneys. M...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:J Am Soc Nephrol
Hauptverfasser: Dwivedi, Nidhi, Tao, Shixin, Jamadar, Abeda, Sinha, Sonali, Howard, Christianna, Wallace, Darren P., Fields, Timothy A., Leask, Andrew, Calvet, James P., Rao, Reena
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Nephrology 2020
Schlagworte:
Basic Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7460894/
https://ncbi.nlm.nih.gov/pubmed/32554753
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2020020190
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge