A Virion-Based Assay for Glycoprotein Thermostability Reveals Key Determinants of Filovirus Entry and Its Inhibition

Ebola virus (EBOV) entry into cells is mediated by its spike glycoprotein (GP). Following attachment and internalization, virions traffic to late endosomes where GP is cleaved by host cysteine proteases. Cleaved GP then binds its cellular receptor, Niemann-Pick C1. In response to an unknown cellular...

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Detalles Bibliográficos
Publicado en:J Virol
Main Authors: Bortz, Robert H., Wong, Anthony C., Grodus, Michael G., Recht, Hannah S., Pulanco, Marc C., Lasso, Gorka, Anthony, Simon J., Mittler, Eva, Jangra, Rohit K., Chandran, Kartik
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2020
Assuntos:
Structure and Assembly
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7459555/
https://ncbi.nlm.nih.gov/pubmed/32611759
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00336-20
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