A Virion-Based Assay for Glycoprotein Thermostability Reveals Key Determinants of Filovirus Entry and Its Inhibition

Ebola virus (EBOV) entry into cells is mediated by its spike glycoprotein (GP). Following attachment and internalization, virions traffic to late endosomes where GP is cleaved by host cysteine proteases. Cleaved GP then binds its cellular receptor, Niemann-Pick C1. In response to an unknown cellular...

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Vydáno v:J Virol
Hlavní autoři: Bortz, Robert H., Wong, Anthony C., Grodus, Michael G., Recht, Hannah S., Pulanco, Marc C., Lasso, Gorka, Anthony, Simon J., Mittler, Eva, Jangra, Rohit K., Chandran, Kartik
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2020
Témata:
Structure and Assembly
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7459555/
https://ncbi.nlm.nih.gov/pubmed/32611759
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00336-20
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