Trehalose ameliorates peritoneal fibrosis by promoting Snail degradation and inhibiting mesothelial-to-mesenchymal transition in mesothelial cells

Peritoneal fibrosis (PF) is a severe complication of peritoneal dialysis, but there are few effective therapies for it. Recent studies have revealed a new biological function of trehalose as an autophagy inducer. Thus far, there are few reports regarding the therapeutic effects of trehalose on fibro...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Miyake, Taito, Sakai, Norihiko, Tamai, Akira, Sato, Koichi, Kamikawa, Yasutaka, Miyagawa, Taro, Ogura, Hisayuki, Yamamura, Yuta, Oshima, Megumi, Nakagawa, Shiori, Sagara, Akihiro, Shinozaki, Yasuyuki, Toyama, Tadashi, Kitajima, Shinji, Hara, Akinori, Iwata, Yasunori, Shimizu, Miho, Furuichi, Kengo, Kaneko, Shuichi, Wada, Takashi
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2020
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7459354/
https://ncbi.nlm.nih.gov/pubmed/32868830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-71230-4
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